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Trophoblasts, invasion, and microRNA

MicroRNAs (miRNAs) have recently become essential actors in various fields of physiology and medicine, especially as easily accessible circulating biomarkers, or as modulators of cell differentiation. To this respect, terminal differentiation of trophoblasts (the characteristic cells of the placenta...

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Autores principales: Doridot, Ludivine, Miralles, Francisco, Barbaux, Sandrine, Vaiman, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836020/
https://www.ncbi.nlm.nih.gov/pubmed/24312123
http://dx.doi.org/10.3389/fgene.2013.00248
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author Doridot, Ludivine
Miralles, Francisco
Barbaux, Sandrine
Vaiman, Daniel
author_facet Doridot, Ludivine
Miralles, Francisco
Barbaux, Sandrine
Vaiman, Daniel
author_sort Doridot, Ludivine
collection PubMed
description MicroRNAs (miRNAs) have recently become essential actors in various fields of physiology and medicine, especially as easily accessible circulating biomarkers, or as modulators of cell differentiation. To this respect, terminal differentiation of trophoblasts (the characteristic cells of the placenta in Therian mammals) into syncytiotrophoblast, villous trophoblast, or extravillous trophoblast constitutes a good example of such a choice, where miRNAs have recently been shown to play an important role. The aim of this review is to provide a snapshot of what is known today in placentation mechanisms that are mediated by miRNA, under the angles of materno–fetal immune dialog regulation, trophoblast differentiation, and angiogenesis at the materno–fetal interface. Also, two aspects of regulation of these issues will be highlighted: the part played by oxygen concentration and the specific function of imprinted genes in the developing placenta.
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spelling pubmed-38360202013-12-05 Trophoblasts, invasion, and microRNA Doridot, Ludivine Miralles, Francisco Barbaux, Sandrine Vaiman, Daniel Front Genet Genetics MicroRNAs (miRNAs) have recently become essential actors in various fields of physiology and medicine, especially as easily accessible circulating biomarkers, or as modulators of cell differentiation. To this respect, terminal differentiation of trophoblasts (the characteristic cells of the placenta in Therian mammals) into syncytiotrophoblast, villous trophoblast, or extravillous trophoblast constitutes a good example of such a choice, where miRNAs have recently been shown to play an important role. The aim of this review is to provide a snapshot of what is known today in placentation mechanisms that are mediated by miRNA, under the angles of materno–fetal immune dialog regulation, trophoblast differentiation, and angiogenesis at the materno–fetal interface. Also, two aspects of regulation of these issues will be highlighted: the part played by oxygen concentration and the specific function of imprinted genes in the developing placenta. Frontiers Media S.A. 2013-11-21 /pmc/articles/PMC3836020/ /pubmed/24312123 http://dx.doi.org/10.3389/fgene.2013.00248 Text en Copyright © 2013 Doridot, Miralles, Barbaux and Vaiman. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Doridot, Ludivine
Miralles, Francisco
Barbaux, Sandrine
Vaiman, Daniel
Trophoblasts, invasion, and microRNA
title Trophoblasts, invasion, and microRNA
title_full Trophoblasts, invasion, and microRNA
title_fullStr Trophoblasts, invasion, and microRNA
title_full_unstemmed Trophoblasts, invasion, and microRNA
title_short Trophoblasts, invasion, and microRNA
title_sort trophoblasts, invasion, and microrna
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836020/
https://www.ncbi.nlm.nih.gov/pubmed/24312123
http://dx.doi.org/10.3389/fgene.2013.00248
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