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The use of lipid-based nanocarriers for targeted pain therapies
Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimizing systemic toxicity. These include the use of biodegradable liposom...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836271/ https://www.ncbi.nlm.nih.gov/pubmed/24319430 http://dx.doi.org/10.3389/fphar.2013.00143 |
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author | Hua, Susan Wu, Sherry Y. |
author_facet | Hua, Susan Wu, Sherry Y. |
author_sort | Hua, Susan |
collection | PubMed |
description | Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimizing systemic toxicity. These include the use of biodegradable liposomal or polymeric carriers. Of these, liposomes present as an attractive delivery system due to their flexible physicochemical properties which allow easy manipulation in order to address different delivery considerations. Their favorable toxicity profiles and ease of large scale production also make their clinical use feasible. In this review, we will discuss the concept of using liposomes as a drug delivery carrier, their in vitro characteristics as well as in vivo behavior. Current advances in the targeted liposomal delivery of analgesic agents and their impacts on the field of pain management will be presented. |
format | Online Article Text |
id | pubmed-3836271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38362712013-12-06 The use of lipid-based nanocarriers for targeted pain therapies Hua, Susan Wu, Sherry Y. Front Pharmacol Pharmacology Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimizing systemic toxicity. These include the use of biodegradable liposomal or polymeric carriers. Of these, liposomes present as an attractive delivery system due to their flexible physicochemical properties which allow easy manipulation in order to address different delivery considerations. Their favorable toxicity profiles and ease of large scale production also make their clinical use feasible. In this review, we will discuss the concept of using liposomes as a drug delivery carrier, their in vitro characteristics as well as in vivo behavior. Current advances in the targeted liposomal delivery of analgesic agents and their impacts on the field of pain management will be presented. Frontiers Media S.A. 2013-11-21 /pmc/articles/PMC3836271/ /pubmed/24319430 http://dx.doi.org/10.3389/fphar.2013.00143 Text en Copyright © 2013 Hua and Wu. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Hua, Susan Wu, Sherry Y. The use of lipid-based nanocarriers for targeted pain therapies |
title | The use of lipid-based nanocarriers for targeted pain therapies |
title_full | The use of lipid-based nanocarriers for targeted pain therapies |
title_fullStr | The use of lipid-based nanocarriers for targeted pain therapies |
title_full_unstemmed | The use of lipid-based nanocarriers for targeted pain therapies |
title_short | The use of lipid-based nanocarriers for targeted pain therapies |
title_sort | use of lipid-based nanocarriers for targeted pain therapies |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836271/ https://www.ncbi.nlm.nih.gov/pubmed/24319430 http://dx.doi.org/10.3389/fphar.2013.00143 |
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