Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK()

Autophagy has been shown to be protective against drug and alcohol-induced liver injury. CYP2E1 plays a role in the toxicity of ethanol, carcinogens and certain drugs. Inhibition of autophagy increased ethanol-toxicity and accumulation of fat in wild type and CYP2E1 knockin mice but not in CYP2E1 kn...

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Detalles Bibliográficos
Autores principales: Wu, Defeng, Cederbaum, Arthur I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836279/
https://www.ncbi.nlm.nih.gov/pubmed/24273738
http://dx.doi.org/10.1016/j.redox.2013.10.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836279/
https://www.ncbi.nlm.nih.gov/pubmed/24273738
http://dx.doi.org/10.1016/j.redox.2013.10.008

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