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The Spindle Assembly Checkpoint works like a rheostat not a toggle-switch

The Spindle Assembly Checkpoint (SAC) is essential in mammalian mitosis to ensure the equal segregation of sister chromatids(1, 2). The SAC generates a Mitotic Checkpoint Complex (MCC) to prevent the Anaphase Promoting Complex/Cyclosome (APC/C) from targeting key mitotic regulators for destruction u...

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Detalles Bibliográficos
Autores principales:	Collin, Philippe, Nashchekina, Oxana, Walker, Rachael, Pines, Jonathon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836401/ https://www.ncbi.nlm.nih.gov/pubmed/24096242 http://dx.doi.org/10.1038/ncb2855

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