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Molecular Dynamic Simulation to Explore the Molecular Basis of Btk-PH Domain Interaction with Ins(1,3,4,5)P4

Bruton's tyrosine kinase contains a pleckstrin homology domain, and it specifically binds inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), which is involved in the maturation of B cells. In this paper, we studied 12 systems including the wild type and 11 mutants, K12R, S14F, K19E, R28C/H, E...

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Detalles Bibliográficos
Autores principales:	Lu, Dan, Jiang, Junfeng, Liang, Zhongjie, Sun, Maomin, Luo, Cheng, Shen, Bairong, Hu, Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836457/ https://www.ncbi.nlm.nih.gov/pubmed/24307874 http://dx.doi.org/10.1155/2013/580456

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