The Flux of Phenolic Compounds through Silicone Membranes

Phenols as a class of molecules have been reported to exhibit higher log maximum fluxes through human stratum corneum, SC, from water, log J(MHAQ), than other classes of molecules. This suggests that their corresponding log maximum fluxes through silicone from water, log J(MPAQ), may be useful to extend the existing n = 63 log J(MPAQ) database to include more log J(MPAQ) values greater than 0.0. The log J(MPAQ) values for n = 7 phenols predicted to give log J(MPAQ) values greater than 0.0 based on their log J(MHAQ) values have been experimentally determined. These n = 7 new log J(MPAQ) values have been added to the existing n = 63 log J(MPAQ) database to give a new n = 70 database and the n = 7 literature log J(MHAQ) values have been added to the existing n = 48 log J(MHAQ) database (matched to the n = 63 log J(MPAQ) database) to give a new n = 55 database. The addition of the n = 7 phenols improved the correlations of these flux databases when fitted to the Roberts-Sloan equation, RS, as well as the correlation between the matched experimental (Exp.) log J(MPAQ) with the Exp. log J(MHAQ).