Deletion of the Murine Cytochrome P450 Cyp2j Locus by Fused BAC-Mediated Recombination Identifies a Role for Cyp2j in the Pulmonary Vascular Response to Hypoxia

Epoxyeicosatrienoic acids (EETs) confer vasoactive and cardioprotective functions. Genetic analysis of the contributions of these short-lived mediators to pathophysiology has been confounded to date by the allelic expansion in rodents of the portion of the genome syntenic to human CYP2J2, a gene enc...

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Detalles Bibliográficos
Autores principales: Zhou, Guo Ling, Beloiartsev, Arkadi, Yu, Binglan, Baron, David M., Zhou, Weihua, Niedra, Rasma, Lu, Naifang, Tainsh, Laurel T., Zapol, Warren M., Seed, Brian, Bloch, Kenneth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836722/
https://www.ncbi.nlm.nih.gov/pubmed/24278032
http://dx.doi.org/10.1371/journal.pgen.1003950

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