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Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin

The polyomavirus family is rapidly expanding with twelve new human viruses identified since 2007. A significant number of the new human polyomaviruses (HPyV) has been found on the skin. Whether these viruses share biological properties and should be grouped together is unknown. Here we investigated...

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Autores principales: van der Meijden, Els, Bialasiewicz, Seweryn, Rockett, Rebecca J., Tozer, Sarah J., Sloots, Theo P., Feltkamp, Mariet C. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836759/
https://www.ncbi.nlm.nih.gov/pubmed/24278381
http://dx.doi.org/10.1371/journal.pone.0081078
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author van der Meijden, Els
Bialasiewicz, Seweryn
Rockett, Rebecca J.
Tozer, Sarah J.
Sloots, Theo P.
Feltkamp, Mariet C. W.
author_facet van der Meijden, Els
Bialasiewicz, Seweryn
Rockett, Rebecca J.
Tozer, Sarah J.
Sloots, Theo P.
Feltkamp, Mariet C. W.
author_sort van der Meijden, Els
collection PubMed
description The polyomavirus family is rapidly expanding with twelve new human viruses identified since 2007. A significant number of the new human polyomaviruses (HPyV) has been found on the skin. Whether these viruses share biological properties and should be grouped together is unknown. Here we investigated the serological behavior of cutaneous HPyVs in a general population. 799 sera from immunocompetent Australian individuals aged between 0–87 were analyzed with a Luminex xMAP technology-based immunoassay for the presence of VP1-directed IgG antibodies against MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, and BKPyV as a control. Except for HPyV9, overall seropositivity was high for the cutanous polyomaviruses (66–81% in adults), and gradually increased with age. Children below 6 months displayed seropositivity rates comparable to the adults, indicative of maternal antibodies. TSPyV seroreactivity levels strongly increased after age 2 and waned later in life comparable to BKPyV, whereas MCPyV, HPyV6 and HPyV7 seroreactivity remained rather stable throughout. Based on the identified serologic profiles, MCPyV seems to cluster with HPyV6 and HPyV7, and TSPyV and HPyV9 by themselves. These profiles indicate heterogeneity among cutaneous polyomaviruses and probably reflect differences in exposure and pathogenic behavior of these viruses.
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spelling pubmed-38367592013-11-25 Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin van der Meijden, Els Bialasiewicz, Seweryn Rockett, Rebecca J. Tozer, Sarah J. Sloots, Theo P. Feltkamp, Mariet C. W. PLoS One Research Article The polyomavirus family is rapidly expanding with twelve new human viruses identified since 2007. A significant number of the new human polyomaviruses (HPyV) has been found on the skin. Whether these viruses share biological properties and should be grouped together is unknown. Here we investigated the serological behavior of cutaneous HPyVs in a general population. 799 sera from immunocompetent Australian individuals aged between 0–87 were analyzed with a Luminex xMAP technology-based immunoassay for the presence of VP1-directed IgG antibodies against MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, and BKPyV as a control. Except for HPyV9, overall seropositivity was high for the cutanous polyomaviruses (66–81% in adults), and gradually increased with age. Children below 6 months displayed seropositivity rates comparable to the adults, indicative of maternal antibodies. TSPyV seroreactivity levels strongly increased after age 2 and waned later in life comparable to BKPyV, whereas MCPyV, HPyV6 and HPyV7 seroreactivity remained rather stable throughout. Based on the identified serologic profiles, MCPyV seems to cluster with HPyV6 and HPyV7, and TSPyV and HPyV9 by themselves. These profiles indicate heterogeneity among cutaneous polyomaviruses and probably reflect differences in exposure and pathogenic behavior of these viruses. Public Library of Science 2013-11-21 /pmc/articles/PMC3836759/ /pubmed/24278381 http://dx.doi.org/10.1371/journal.pone.0081078 Text en © 2013 van der Meijden et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
van der Meijden, Els
Bialasiewicz, Seweryn
Rockett, Rebecca J.
Tozer, Sarah J.
Sloots, Theo P.
Feltkamp, Mariet C. W.
Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin
title Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin
title_full Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin
title_fullStr Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin
title_full_unstemmed Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin
title_short Different Serologic Behavior of MCPyV, TSPyV, HPyV6, HPyV7 and HPyV9 Polyomaviruses Found on the Skin
title_sort different serologic behavior of mcpyv, tspyv, hpyv6, hpyv7 and hpyv9 polyomaviruses found on the skin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836759/
https://www.ncbi.nlm.nih.gov/pubmed/24278381
http://dx.doi.org/10.1371/journal.pone.0081078
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