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Complete Atrial-Specific Knockout of Sodium-Calcium Exchange Eliminates Sinoatrial Node Pacemaker Activity

The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by “funny” current (I(f)) through HCN4 channels (the “Membrane Clock“ hypothesis), depolarization by cardiac Na-Ca exchange (NCX1) in response to intracellular Ca...

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Detalles Bibliográficos
Autores principales:	Groenke, Sabine, Larson, Eric D., Alber, Sarah, Zhang, Rui, Lamp, Scott T., Ren, Xiaoyan, Nakano, Haruko, Jordan, Maria C., Karagueuzian, Hrayr S., Roos, Kenneth P., Nakano, Atsushi, Proenza, Catherine, Philipson, Kenneth D., Goldhaber, Joshua I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836769/ https://www.ncbi.nlm.nih.gov/pubmed/24278453 http://dx.doi.org/10.1371/journal.pone.0081633

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