Understanding the Connection between Epigenetic DNA Methylation and Nucleosome Positioning from Computer Simulations

Cytosine methylation is one of the most important epigenetic marks that regulate the process of gene expression. Here, we have examined the effect of epigenetic DNA methylation on nucleosomal stability using molecular dynamics simulations and elastic deformation models. We found that methylation of...

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Detalles Bibliográficos
Autores principales: Portella, Guillem, Battistini, Federica, Orozco, Modesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836855/
https://www.ncbi.nlm.nih.gov/pubmed/24278005
http://dx.doi.org/10.1371/journal.pcbi.1003354

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