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Early chronic kidney disease-mineral bone disorder stimulates vascular calcification
The chronic kidney disease-mineral and bone disorder (CKD-MBD) syndrome is an extremely important complication of kidney diseases. Here we tested whether CKD-MBD causes vascular calcification in early kidney failure by developing a mouse model of early CKD in a background of atherosclerosis stimulat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836911/ https://www.ncbi.nlm.nih.gov/pubmed/23884339 http://dx.doi.org/10.1038/ki.2013.271 |
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author | Fang, Yifu Ginsberg, Charles Sugatani, Toshifumi Monier-Faugere, Marie-Claude Malluche, Hartmut Hruska, Keith A |
author_facet | Fang, Yifu Ginsberg, Charles Sugatani, Toshifumi Monier-Faugere, Marie-Claude Malluche, Hartmut Hruska, Keith A |
author_sort | Fang, Yifu |
collection | PubMed |
description | The chronic kidney disease-mineral and bone disorder (CKD-MBD) syndrome is an extremely important complication of kidney diseases. Here we tested whether CKD-MBD causes vascular calcification in early kidney failure by developing a mouse model of early CKD in a background of atherosclerosis stimulated arterial calcification. CKD equivalent in glomerular filtration reduction to human CKD stage 2 stimulated early vascular calcification and inhibited the tissue expression of α-klotho (klotho) in the aorta. In addition, osteoblast transition in the aorta was stimulated by early CKD as shown by the expression of the critical transcription factor, RUNX2. The ligand associated with the klotho-fibroblast growth factor receptor complex, FGF23, was found to be expressed in the vascular media of sham operated mice. Its expression was decreased in early CKD. Increased circulating levels of the osteocyte secreted proteins, FGF23, and sclerostin may have been related to increased circulating klotho levels. Finally, we observed low turnover bone disease with a reduction in bone formation rates more than bone resorption. Thus, the CKD-MBD, characterized by cardiovascular risk factors, vascular calcification, increased circulating klotho, FGF23 and sclerostin levels, and low turnover renal osteodystrophy, was established in early CKD. Early CKD caused a reduction of vascular klotho, stimulated vascular osteoblastic transition, increased osteocytic secreted proteins, and inhibited skeletal modeling producing the CKD-MBD. |
format | Online Article Text |
id | pubmed-3836911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-38369112014-07-01 Early chronic kidney disease-mineral bone disorder stimulates vascular calcification Fang, Yifu Ginsberg, Charles Sugatani, Toshifumi Monier-Faugere, Marie-Claude Malluche, Hartmut Hruska, Keith A Kidney Int Article The chronic kidney disease-mineral and bone disorder (CKD-MBD) syndrome is an extremely important complication of kidney diseases. Here we tested whether CKD-MBD causes vascular calcification in early kidney failure by developing a mouse model of early CKD in a background of atherosclerosis stimulated arterial calcification. CKD equivalent in glomerular filtration reduction to human CKD stage 2 stimulated early vascular calcification and inhibited the tissue expression of α-klotho (klotho) in the aorta. In addition, osteoblast transition in the aorta was stimulated by early CKD as shown by the expression of the critical transcription factor, RUNX2. The ligand associated with the klotho-fibroblast growth factor receptor complex, FGF23, was found to be expressed in the vascular media of sham operated mice. Its expression was decreased in early CKD. Increased circulating levels of the osteocyte secreted proteins, FGF23, and sclerostin may have been related to increased circulating klotho levels. Finally, we observed low turnover bone disease with a reduction in bone formation rates more than bone resorption. Thus, the CKD-MBD, characterized by cardiovascular risk factors, vascular calcification, increased circulating klotho, FGF23 and sclerostin levels, and low turnover renal osteodystrophy, was established in early CKD. Early CKD caused a reduction of vascular klotho, stimulated vascular osteoblastic transition, increased osteocytic secreted proteins, and inhibited skeletal modeling producing the CKD-MBD. 2013-07-24 2014-01 /pmc/articles/PMC3836911/ /pubmed/23884339 http://dx.doi.org/10.1038/ki.2013.271 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Fang, Yifu Ginsberg, Charles Sugatani, Toshifumi Monier-Faugere, Marie-Claude Malluche, Hartmut Hruska, Keith A Early chronic kidney disease-mineral bone disorder stimulates vascular calcification |
title | Early chronic kidney disease-mineral bone disorder stimulates vascular calcification |
title_full | Early chronic kidney disease-mineral bone disorder stimulates vascular calcification |
title_fullStr | Early chronic kidney disease-mineral bone disorder stimulates vascular calcification |
title_full_unstemmed | Early chronic kidney disease-mineral bone disorder stimulates vascular calcification |
title_short | Early chronic kidney disease-mineral bone disorder stimulates vascular calcification |
title_sort | early chronic kidney disease-mineral bone disorder stimulates vascular calcification |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836911/ https://www.ncbi.nlm.nih.gov/pubmed/23884339 http://dx.doi.org/10.1038/ki.2013.271 |
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