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SIRT1 Catalytic Activity Has Little Effect on Tumor Formation and Metastases in a Mouse Model of Breast Cancer

The protein deacetylase SIRT1 has been implicated in the regulation of a large number of cellular processes that are thought to be required for cancer initiation and progression. There are conflicting data that make it unclear whether Sirt1 functions as an oncogene or tumor suppressor. To assess the...

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Detalles Bibliográficos
Autores principales:	Clark-Knowles, Katherine V., Dewar-Darch, Danielle, Jardine, Karen E., McBurney, Michael W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836945/ https://www.ncbi.nlm.nih.gov/pubmed/24278473 http://dx.doi.org/10.1371/journal.pone.0082106

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