Correlation of Chromosomal Instability, Telomere Length and Telomere Maintenance in Microsatellite Stable Rectal Cancer: A Molecular Subclass of Rectal Cancer

INTRODUCTION: Colorectal cancer (CRC) tumor DNA is characterized by chromosomal damage termed chromosomal instability (CIN) and excessively shortened telomeres. Up to 80% of CRC is microsatellite stable (MSS) and is historically considered to be chromosomally unstable (CIN+). However, tumor phenotyp...

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Detalles Bibliográficos
Autores principales: Boardman, Lisa A., Johnson, Ruth A., Viker, Kimberly B., Hafner, Kari A., Jenkins, Robert B., Riegert-Johnson, Douglas L., Smyrk, Thomas C., Litzelman, Kristin, Seo, Songwon, Gangnon, Ronald E., Engelman, Corinne D., Rider, David N., Vanderboom, Russell J., Thibodeau, Stephen N., Petersen, Gloria M., Skinner, Halcyon G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836975/
https://www.ncbi.nlm.nih.gov/pubmed/24278232
http://dx.doi.org/10.1371/journal.pone.0080015

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