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NLRC5, at the Heart of Antigen Presentation

Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has b...

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Autores principales: Neerincx, Andreas, Castro, Wilson, Guarda, Greta, Kufer, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837245/
https://www.ncbi.nlm.nih.gov/pubmed/24319445
http://dx.doi.org/10.3389/fimmu.2013.00397
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author Neerincx, Andreas
Castro, Wilson
Guarda, Greta
Kufer, Thomas A.
author_facet Neerincx, Andreas
Castro, Wilson
Guarda, Greta
Kufer, Thomas A.
author_sort Neerincx, Andreas
collection PubMed
description Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has been a matter of debate. It is now clear that NLRC5 acts as a transcriptional regulator of the major-histocompatibility complex class I. In this review we detail the development of our understanding of NLRC5 function, discussing both the accepted and the controversial aspects of NLRC5 activity. We give insight into the molecular mechanisms, and the potential implications, of NLRC5 function in health and disease.
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spelling pubmed-38372452013-12-06 NLRC5, at the Heart of Antigen Presentation Neerincx, Andreas Castro, Wilson Guarda, Greta Kufer, Thomas A. Front Immunol Immunology Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has been a matter of debate. It is now clear that NLRC5 acts as a transcriptional regulator of the major-histocompatibility complex class I. In this review we detail the development of our understanding of NLRC5 function, discussing both the accepted and the controversial aspects of NLRC5 activity. We give insight into the molecular mechanisms, and the potential implications, of NLRC5 function in health and disease. Frontiers Media S.A. 2013-11-22 /pmc/articles/PMC3837245/ /pubmed/24319445 http://dx.doi.org/10.3389/fimmu.2013.00397 Text en Copyright © 2013 Neerincx, Castro, Guarda and Kufer. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Neerincx, Andreas
Castro, Wilson
Guarda, Greta
Kufer, Thomas A.
NLRC5, at the Heart of Antigen Presentation
title NLRC5, at the Heart of Antigen Presentation
title_full NLRC5, at the Heart of Antigen Presentation
title_fullStr NLRC5, at the Heart of Antigen Presentation
title_full_unstemmed NLRC5, at the Heart of Antigen Presentation
title_short NLRC5, at the Heart of Antigen Presentation
title_sort nlrc5, at the heart of antigen presentation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837245/
https://www.ncbi.nlm.nih.gov/pubmed/24319445
http://dx.doi.org/10.3389/fimmu.2013.00397
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