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The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology

The cancer stem cell theory entails the existence of a hierarchically organized, rare population of cells which are responsible for tumor initiation, self-renewal/maintenance, and mutation accumulation. The cancer stem cell proposition could explain the high frequency of cancer relapse and resistanc...

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Detalles Bibliográficos
Autores principales:	Martelli, Alberto M., Evangelisti, Camilla, Chiarini, Francesca, Grimaldi, Cecilia, McCubrey, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837323/ https://www.ncbi.nlm.nih.gov/pubmed/24281174 http://dx.doi.org/10.3390/cancers2031576

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