Cancer Stem Cells in Pancreatic Cancer

Pancreatic cancer is an aggressive malignant solid tumor well-known by early metastasis, local invasion, resistance to standard chemo- and radiotherapy and poor prognosis. Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). Here we review the...

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Detalles Bibliográficos
Autores principales: Bao, Qi, Zhao, Yue, Renner, Andrea, Niess, Hanno, Seeliger, Hendrik, Jauch, Karl-Walter, Bruns, Christiane J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837327/
https://www.ncbi.nlm.nih.gov/pubmed/24281178
http://dx.doi.org/10.3390/cancers2031629
Descripción
Sumario:Pancreatic cancer is an aggressive malignant solid tumor well-known by early metastasis, local invasion, resistance to standard chemo- and radiotherapy and poor prognosis. Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). Here we review the current research results regarding CSCs in pancreatic cancer and discuss the different markers identifying pancreatic CSCs. This review will focus on metastasis, microRNA regulation and anti-CSC therapy in pancreatic cancer.

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