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Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system

The ability to take advantage of plasminogen and its activated form plasmin is a common mechanism used by commensal as well as pathogenic bacteria in interaction with their respective host. Hence, a huge variety of plasminogen binding proteins and activation mechanisms exist. This review solely focu...

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Detalles Bibliográficos
Autores principales: Fulde, Marcus, Steinert, Michael, Bergmann, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837353/
https://www.ncbi.nlm.nih.gov/pubmed/24319673
http://dx.doi.org/10.3389/fcimb.2013.00085
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author Fulde, Marcus
Steinert, Michael
Bergmann, Simone
author_facet Fulde, Marcus
Steinert, Michael
Bergmann, Simone
author_sort Fulde, Marcus
collection PubMed
description The ability to take advantage of plasminogen and its activated form plasmin is a common mechanism used by commensal as well as pathogenic bacteria in interaction with their respective host. Hence, a huge variety of plasminogen binding proteins and activation mechanisms exist. This review solely focuses on the genus Streptococcus and, in particular, on the so-called non-activating plasminogen binding proteins. Based on structural and functional differences, as well as on their mode of surface linkaging, three groups can be assigned: M-(like) proteins, surface displayed cytoplasmatic proteins with enzymatic activities (“moonlighting proteins”) and other surface proteins. Here, the plasminogen binding sites and the interaction mechanisms are compared. Recent findings on the functional consequences of these interactions on tissue degradation and immune evasion are summarized.
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spelling pubmed-38373532013-12-06 Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system Fulde, Marcus Steinert, Michael Bergmann, Simone Front Cell Infect Microbiol Microbiology The ability to take advantage of plasminogen and its activated form plasmin is a common mechanism used by commensal as well as pathogenic bacteria in interaction with their respective host. Hence, a huge variety of plasminogen binding proteins and activation mechanisms exist. This review solely focuses on the genus Streptococcus and, in particular, on the so-called non-activating plasminogen binding proteins. Based on structural and functional differences, as well as on their mode of surface linkaging, three groups can be assigned: M-(like) proteins, surface displayed cytoplasmatic proteins with enzymatic activities (“moonlighting proteins”) and other surface proteins. Here, the plasminogen binding sites and the interaction mechanisms are compared. Recent findings on the functional consequences of these interactions on tissue degradation and immune evasion are summarized. Frontiers Media S.A. 2013-11-22 /pmc/articles/PMC3837353/ /pubmed/24319673 http://dx.doi.org/10.3389/fcimb.2013.00085 Text en Copyright © 2013 Fulde, Steinert and Bergmann. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Fulde, Marcus
Steinert, Michael
Bergmann, Simone
Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system
title Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system
title_full Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system
title_fullStr Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system
title_full_unstemmed Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system
title_short Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system
title_sort interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837353/
https://www.ncbi.nlm.nih.gov/pubmed/24319673
http://dx.doi.org/10.3389/fcimb.2013.00085
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