Pseudorabies Virus Variant in Bartha-K61–Vaccinated Pigs, China, 2012

The widely used pseudorabies virus (PRV) Bartha-K61 vaccine has played a key role in the eradication of PRV. Since late 2011, however, a disease characterized by neurologic symptoms and a high number of deaths among newborn piglets has occurred among Bartha-K61–vaccinated pigs on many farms in China...

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Detalles Bibliográficos
Autores principales: An, Tong-Qing, Peng, Jin-Mei, Tian, Zhi-Jun, Zhao, Hong-Yuan, Li, Na, Liu, Yi-Min, Chen, Jia-Zeng, Leng, Chao-Liang, Sun, Yan, Chang, Dan, Tong, Guang-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837674/
https://www.ncbi.nlm.nih.gov/pubmed/24188614
http://dx.doi.org/10.3201/eid1911.130177
Descripción
Sumario:The widely used pseudorabies virus (PRV) Bartha-K61 vaccine has played a key role in the eradication of PRV. Since late 2011, however, a disease characterized by neurologic symptoms and a high number of deaths among newborn piglets has occurred among Bartha-K61–vaccinated pigs on many farms in China. Clinical samples from pigs on 15 farms in 6 provinces were examined. The PRV gE gene was detectable by PCR in all samples, and sequence analysis of the gE gene showed that all isolates belonged to a relatively independent cluster and contained 2 amino acid insertions. A PRV (named HeN1) was isolated and caused transitional fever in pigs. In protection assays, Bartha-K61 vaccine provided 100% protection against lethal challenge with SC (a classical PRV) but only 50% protection against 4 challenges with strain HeN1. The findings suggest that Bartha-K61 vaccine does not provide effective protection against PRV HeN1 infection.

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