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Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008
Understanding global influenza migration and persistence is crucial for vaccine strain selection. Using 240 new human influenza A virus whole genomes collected in Vietnam during 2001–2008, we looked for persistence patterns and migratory connections between Vietnam and other countries. We found that...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837676/ https://www.ncbi.nlm.nih.gov/pubmed/24188643 http://dx.doi.org/10.3201/eid1911.130349 |
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author | Le, Mai Quynh Lam, Ha Minh Cuong, Vuong Duc Lam, Tommy Tsan-Yuk Halpin, Rebecca A Wentworth, David E Hien, Nguyen Tran Thanh, Le Thi Phuong, Hoang Vu Mai Horby, Peter Boni, Maciej F. |
author_facet | Le, Mai Quynh Lam, Ha Minh Cuong, Vuong Duc Lam, Tommy Tsan-Yuk Halpin, Rebecca A Wentworth, David E Hien, Nguyen Tran Thanh, Le Thi Phuong, Hoang Vu Mai Horby, Peter Boni, Maciej F. |
author_sort | Le, Mai Quynh |
collection | PubMed |
description | Understanding global influenza migration and persistence is crucial for vaccine strain selection. Using 240 new human influenza A virus whole genomes collected in Vietnam during 2001–2008, we looked for persistence patterns and migratory connections between Vietnam and other countries. We found that viruses in Vietnam migrate to and from China, Hong Kong, Taiwan, Cambodia, Japan, South Korea, and the United States. We attempted to reduce geographic bias by generating phylogenies subsampled at the year and country levels. However, migration events in these phylogenies were still driven by the presence or absence of sequence data, indicating that an epidemiologic study design that controls for prevalence is required for robust migration analysis. With whole-genome data, most migration events are not detectable from the phylogeny of the hemagglutinin segment alone, although general migratory relationships between Vietnam and other countries are visible in the hemagglutinin phylogeny. It is possible that virus lineages in Vietnam persisted for >1 year. |
format | Online Article Text |
id | pubmed-3837676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-38376762013-11-22 Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008 Le, Mai Quynh Lam, Ha Minh Cuong, Vuong Duc Lam, Tommy Tsan-Yuk Halpin, Rebecca A Wentworth, David E Hien, Nguyen Tran Thanh, Le Thi Phuong, Hoang Vu Mai Horby, Peter Boni, Maciej F. Emerg Infect Dis Research Understanding global influenza migration and persistence is crucial for vaccine strain selection. Using 240 new human influenza A virus whole genomes collected in Vietnam during 2001–2008, we looked for persistence patterns and migratory connections between Vietnam and other countries. We found that viruses in Vietnam migrate to and from China, Hong Kong, Taiwan, Cambodia, Japan, South Korea, and the United States. We attempted to reduce geographic bias by generating phylogenies subsampled at the year and country levels. However, migration events in these phylogenies were still driven by the presence or absence of sequence data, indicating that an epidemiologic study design that controls for prevalence is required for robust migration analysis. With whole-genome data, most migration events are not detectable from the phylogeny of the hemagglutinin segment alone, although general migratory relationships between Vietnam and other countries are visible in the hemagglutinin phylogeny. It is possible that virus lineages in Vietnam persisted for >1 year. Centers for Disease Control and Prevention 2013-11 /pmc/articles/PMC3837676/ /pubmed/24188643 http://dx.doi.org/10.3201/eid1911.130349 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Le, Mai Quynh Lam, Ha Minh Cuong, Vuong Duc Lam, Tommy Tsan-Yuk Halpin, Rebecca A Wentworth, David E Hien, Nguyen Tran Thanh, Le Thi Phuong, Hoang Vu Mai Horby, Peter Boni, Maciej F. Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008 |
title | Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008 |
title_full | Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008 |
title_fullStr | Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008 |
title_full_unstemmed | Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008 |
title_short | Migration and Persistence of Human Influenza A Viruses, Vietnam, 2001–2008 |
title_sort | migration and persistence of human influenza a viruses, vietnam, 2001–2008 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837676/ https://www.ncbi.nlm.nih.gov/pubmed/24188643 http://dx.doi.org/10.3201/eid1911.130349 |
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