Cargando…

Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study

BACKGROUND: As vitamin D may have a neuroprotective effect, the authors studied the association of biomarkers of vitamin D status and delirium to see if low vitamin D status was common in delirium cases. METHODS: Biochemical measures of vitamin D (25-hydroxyvitamin D [25-OHD]) and calcium metabolism...

Descripción completa

Detalles Bibliográficos
Autores principales: Ford, Jennifer, Hategan, Ana, Bourgeois, James A., Tisi, Daniel K., Xiong, Glen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Canadian Geriatrics Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837717/
https://www.ncbi.nlm.nih.gov/pubmed/24278095
http://dx.doi.org/10.5770/cgj.16.79
Descripción
Sumario:BACKGROUND: As vitamin D may have a neuroprotective effect, the authors studied the association of biomarkers of vitamin D status and delirium to see if low vitamin D status was common in delirium cases. METHODS: Biochemical measures of vitamin D (25-hydroxyvitamin D [25-OHD]) and calcium metabolism were used in this retrospective cross-sectional analysis of adult in-patients with delirium, admitted at three Canadian academic hospitals from January 2011 to July 2012. Primary outcome was to determine estimates of the prevalence of hypovitaminosis D in this group in whom vitamin D was checked. RESULTS: Seventy-one (5.8%) out of 1,232 delirium inpatients had their vitamin D measured. Thirty-nine (55%) showed vitamin D insufficiency (25-OHD of 25-75 nmol/L) and 8 (11%) showed vitamin D deficiency (25-OHD < 25 nmol/L). Mean serum 25-OHD levels were lower in males (57.1±7.7 nmol/L) than in females (78.2±6.1 nmol/L), p = .01, even when controlled for age and season. Men were younger than the women (74.4±2.3 vs. 82.4±1.7, p = .005). Mean age was 78.7±1.5 years, and 33 (47%) were male. CONCLUSIONS: Although vitamin D is rarely checked during delirium workup and/or management, high rates of hypovitaminosis D were found to be common in the delirium in-patients in whom it was checked. Larger studies would be needed to estimate the prevalence of hypovitaminosis D in delirium and whether hypovitaminosis D plays a role in the pathogenesis of delirium.