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Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study

BACKGROUND: As vitamin D may have a neuroprotective effect, the authors studied the association of biomarkers of vitamin D status and delirium to see if low vitamin D status was common in delirium cases. METHODS: Biochemical measures of vitamin D (25-hydroxyvitamin D [25-OHD]) and calcium metabolism...

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Autores principales: Ford, Jennifer, Hategan, Ana, Bourgeois, James A., Tisi, Daniel K., Xiong, Glen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Canadian Geriatrics Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837717/
https://www.ncbi.nlm.nih.gov/pubmed/24278095
http://dx.doi.org/10.5770/cgj.16.79
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author Ford, Jennifer
Hategan, Ana
Bourgeois, James A.
Tisi, Daniel K.
Xiong, Glen L.
author_facet Ford, Jennifer
Hategan, Ana
Bourgeois, James A.
Tisi, Daniel K.
Xiong, Glen L.
author_sort Ford, Jennifer
collection PubMed
description BACKGROUND: As vitamin D may have a neuroprotective effect, the authors studied the association of biomarkers of vitamin D status and delirium to see if low vitamin D status was common in delirium cases. METHODS: Biochemical measures of vitamin D (25-hydroxyvitamin D [25-OHD]) and calcium metabolism were used in this retrospective cross-sectional analysis of adult in-patients with delirium, admitted at three Canadian academic hospitals from January 2011 to July 2012. Primary outcome was to determine estimates of the prevalence of hypovitaminosis D in this group in whom vitamin D was checked. RESULTS: Seventy-one (5.8%) out of 1,232 delirium inpatients had their vitamin D measured. Thirty-nine (55%) showed vitamin D insufficiency (25-OHD of 25-75 nmol/L) and 8 (11%) showed vitamin D deficiency (25-OHD < 25 nmol/L). Mean serum 25-OHD levels were lower in males (57.1±7.7 nmol/L) than in females (78.2±6.1 nmol/L), p = .01, even when controlled for age and season. Men were younger than the women (74.4±2.3 vs. 82.4±1.7, p = .005). Mean age was 78.7±1.5 years, and 33 (47%) were male. CONCLUSIONS: Although vitamin D is rarely checked during delirium workup and/or management, high rates of hypovitaminosis D were found to be common in the delirium in-patients in whom it was checked. Larger studies would be needed to estimate the prevalence of hypovitaminosis D in delirium and whether hypovitaminosis D plays a role in the pathogenesis of delirium.
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spelling pubmed-38377172013-11-25 Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study Ford, Jennifer Hategan, Ana Bourgeois, James A. Tisi, Daniel K. Xiong, Glen L. Can Geriatr J Original Research BACKGROUND: As vitamin D may have a neuroprotective effect, the authors studied the association of biomarkers of vitamin D status and delirium to see if low vitamin D status was common in delirium cases. METHODS: Biochemical measures of vitamin D (25-hydroxyvitamin D [25-OHD]) and calcium metabolism were used in this retrospective cross-sectional analysis of adult in-patients with delirium, admitted at three Canadian academic hospitals from January 2011 to July 2012. Primary outcome was to determine estimates of the prevalence of hypovitaminosis D in this group in whom vitamin D was checked. RESULTS: Seventy-one (5.8%) out of 1,232 delirium inpatients had their vitamin D measured. Thirty-nine (55%) showed vitamin D insufficiency (25-OHD of 25-75 nmol/L) and 8 (11%) showed vitamin D deficiency (25-OHD < 25 nmol/L). Mean serum 25-OHD levels were lower in males (57.1±7.7 nmol/L) than in females (78.2±6.1 nmol/L), p = .01, even when controlled for age and season. Men were younger than the women (74.4±2.3 vs. 82.4±1.7, p = .005). Mean age was 78.7±1.5 years, and 33 (47%) were male. CONCLUSIONS: Although vitamin D is rarely checked during delirium workup and/or management, high rates of hypovitaminosis D were found to be common in the delirium in-patients in whom it was checked. Larger studies would be needed to estimate the prevalence of hypovitaminosis D in delirium and whether hypovitaminosis D plays a role in the pathogenesis of delirium. Canadian Geriatrics Society 2013-12-03 /pmc/articles/PMC3837717/ /pubmed/24278095 http://dx.doi.org/10.5770/cgj.16.79 Text en © 2013 Author(s). Published by the Canadian Geriatrics Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No-Derivative license (http://creativecommons.org/licenses/by-nc-nd/2.5/ca/), which permits unrestricted non-commercial use and distribution, provided the original work is properly cited.
spellingShingle Original Research
Ford, Jennifer
Hategan, Ana
Bourgeois, James A.
Tisi, Daniel K.
Xiong, Glen L.
Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study
title Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study
title_full Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study
title_fullStr Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study
title_full_unstemmed Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study
title_short Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study
title_sort hypovitaminosis d in delirium: a retrospective cross-sectional study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837717/
https://www.ncbi.nlm.nih.gov/pubmed/24278095
http://dx.doi.org/10.5770/cgj.16.79
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