The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm

The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to...

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Autores principales: Xiao, Han, Killip, Marian J., Staeheli, Peter, Randall, Richard E., Jackson, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2013
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838145/
https://www.ncbi.nlm.nih.gov/pubmed/24049170
http://dx.doi.org/10.1128/JVI.02220-13
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author Xiao, Han
Killip, Marian J.
Staeheli, Peter
Randall, Richard E.
Jackson, David
author_facet Xiao, Han
Killip, Marian J.
Staeheli, Peter
Randall, Richard E.
Jackson, David
author_sort Xiao, Han
collection PubMed
description The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and that the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.
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spelling pubmed-38381452013-12-18 The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm Xiao, Han Killip, Marian J. Staeheli, Peter Randall, Richard E. Jackson, David J Virol Pathogenesis and Immunity The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and that the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection. American Society for Microbiology 2013-12 /pmc/articles/PMC3838145/ /pubmed/24049170 http://dx.doi.org/10.1128/JVI.02220-13 Text en Copyright © 2013 Xiao et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Pathogenesis and Immunity
Xiao, Han
Killip, Marian J.
Staeheli, Peter
Randall, Richard E.
Jackson, David
The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
title The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
title_full The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
title_fullStr The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
title_full_unstemmed The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
title_short The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm
title_sort human interferon-induced mxa protein inhibits early stages of influenza a virus infection by retaining the incoming viral genome in the cytoplasm
topic Pathogenesis and Immunity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838145/
https://www.ncbi.nlm.nih.gov/pubmed/24049170
http://dx.doi.org/10.1128/JVI.02220-13
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