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The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm

The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here, we show that a preexisting antiviral state inhibits the replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to...

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Detalles Bibliográficos
Autores principales:	Xiao, Han, Killip, Marian J., Staeheli, Peter, Randall, Richard E., Jackson, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2013
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838145/ https://www.ncbi.nlm.nih.gov/pubmed/24049170 http://dx.doi.org/10.1128/JVI.02220-13

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