A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans

Loss of germline precursor cells in C. elegans has previously been shown to improve protein homeostasis and extend lifespan, possibly due to reallocation of resources to somatic cells. In contrast, mutants that are sterile simply due to loss of sperm or oocyte production have a normal lifespan, ofte...

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Detalles Bibliográficos
Autores principales: Angeli, Suzanne, Klang, Ida, Sivapatham, Renuka, Mark, Karla, Zucker, David, Bhaumik, Dipa, Lithgow, Gordon J., Andersen, Julie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838778/
https://www.ncbi.nlm.nih.gov/pubmed/24123581

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