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PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

In the liver, insulin suppresses hepatic gluconeogenesis by activating Akt, which inactivates the key gluconeogenic transcription factor FoxO1 (Forkhead Box O1). Recent studies have implicated hyperactivity of the Akt phosphatase Protein Phosphatase 2A (PP2A) and impaired Akt signaling as a molecula...

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Detalles Bibliográficos
Autores principales:	Galbo, Thomas, Perry, Rachel J., Nishimura, Erica, Samuel, Varman T., Quistorff, Bjørn, Shulman, Gerald I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838779/ https://www.ncbi.nlm.nih.gov/pubmed/24150286

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