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A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838820/ https://www.ncbi.nlm.nih.gov/pubmed/24312913 http://dx.doi.org/10.1155/2013/928562 |
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author | Karami, Fatemeh Mehdipour, Parvin |
author_facet | Karami, Fatemeh Mehdipour, Parvin |
author_sort | Karami, Fatemeh |
collection | PubMed |
description | Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important BRCA1 and BRCA2 alterations which have been encountered in most of the populations. After those Ashkenazi founder mutations, 300T>G also demonstrated sparse frequency in African American and European populations. This review affords quick access to the most frequent alterations among various populations which could be helpful in BRCA screening programs. |
format | Online Article Text |
id | pubmed-3838820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38388202013-12-05 A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer Karami, Fatemeh Mehdipour, Parvin Biomed Res Int Review Article Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important BRCA1 and BRCA2 alterations which have been encountered in most of the populations. After those Ashkenazi founder mutations, 300T>G also demonstrated sparse frequency in African American and European populations. This review affords quick access to the most frequent alterations among various populations which could be helpful in BRCA screening programs. Hindawi Publishing Corporation 2013 2013-11-07 /pmc/articles/PMC3838820/ /pubmed/24312913 http://dx.doi.org/10.1155/2013/928562 Text en Copyright © 2013 F. Karami and P. Mehdipour. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Karami, Fatemeh Mehdipour, Parvin A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer |
title | A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer |
title_full | A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer |
title_fullStr | A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer |
title_full_unstemmed | A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer |
title_short | A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer |
title_sort | comprehensive focus on global spectrum of brca1 and brca2 mutations in breast cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838820/ https://www.ncbi.nlm.nih.gov/pubmed/24312913 http://dx.doi.org/10.1155/2013/928562 |
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