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A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer

Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC...

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Detalles Bibliográficos
Autores principales: Karami, Fatemeh, Mehdipour, Parvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838820/
https://www.ncbi.nlm.nih.gov/pubmed/24312913
http://dx.doi.org/10.1155/2013/928562
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author Karami, Fatemeh
Mehdipour, Parvin
author_facet Karami, Fatemeh
Mehdipour, Parvin
author_sort Karami, Fatemeh
collection PubMed
description Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important BRCA1 and BRCA2 alterations which have been encountered in most of the populations. After those Ashkenazi founder mutations, 300T>G also demonstrated sparse frequency in African American and European populations. This review affords quick access to the most frequent alterations among various populations which could be helpful in BRCA screening programs.
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spelling pubmed-38388202013-12-05 A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer Karami, Fatemeh Mehdipour, Parvin Biomed Res Int Review Article Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important BRCA1 and BRCA2 alterations which have been encountered in most of the populations. After those Ashkenazi founder mutations, 300T>G also demonstrated sparse frequency in African American and European populations. This review affords quick access to the most frequent alterations among various populations which could be helpful in BRCA screening programs. Hindawi Publishing Corporation 2013 2013-11-07 /pmc/articles/PMC3838820/ /pubmed/24312913 http://dx.doi.org/10.1155/2013/928562 Text en Copyright © 2013 F. Karami and P. Mehdipour. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Karami, Fatemeh
Mehdipour, Parvin
A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
title A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
title_full A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
title_fullStr A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
title_full_unstemmed A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
title_short A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
title_sort comprehensive focus on global spectrum of brca1 and brca2 mutations in breast cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838820/
https://www.ncbi.nlm.nih.gov/pubmed/24312913
http://dx.doi.org/10.1155/2013/928562
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