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Diabetes and the Metabolic Syndrome: Possibilities of a New Breath Test in a Dolphin Model

Diabetes type-2 and the metabolic syndrome are prevalent in epidemic proportions and result in significant co-morbid disease. Limitations in understanding of dietary effects and cholesterol metabolism exist. Current methods to assess diabetes are essential, though many are invasive; for example, blo...

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Autores principales: Schivo, Michael, Aksenov, Alexander A., Yeates, Laura C., Pasamontes, Alberto, Davis, Cristina E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839089/
https://www.ncbi.nlm.nih.gov/pubmed/24324455
http://dx.doi.org/10.3389/fendo.2013.00163
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author Schivo, Michael
Aksenov, Alexander A.
Yeates, Laura C.
Pasamontes, Alberto
Davis, Cristina E.
author_facet Schivo, Michael
Aksenov, Alexander A.
Yeates, Laura C.
Pasamontes, Alberto
Davis, Cristina E.
author_sort Schivo, Michael
collection PubMed
description Diabetes type-2 and the metabolic syndrome are prevalent in epidemic proportions and result in significant co-morbid disease. Limitations in understanding of dietary effects and cholesterol metabolism exist. Current methods to assess diabetes are essential, though many are invasive; for example, blood glucose and lipid monitoring require regular finger sticks and blood draws. A novel method to study these diseases may be non-invasive breath testing of exhaled compounds. Currently, acetone and lipid peroxidation products have been seen in small scale studies, though other compounds may be significant. As Atlantic bottlenose dolphins (Tursiops truncatus) have been proposed as a good model for human diabetes, applications of dietary manipulations and breath testing in this population may shed important light on how to design human clinical studies. In addition, ongoing studies indicate that breath testing in dolphins is feasible, humane, and yields relevant metabolites. By studying the metabolic and cholesterol responses of dolphins to dietary modifications, researchers may gain insight into human diabetes, improve the design of costly human clinical trials, and potentially discover biomarkers for non-invasive breath monitoring.
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spelling pubmed-38390892013-12-09 Diabetes and the Metabolic Syndrome: Possibilities of a New Breath Test in a Dolphin Model Schivo, Michael Aksenov, Alexander A. Yeates, Laura C. Pasamontes, Alberto Davis, Cristina E. Front Endocrinol (Lausanne) Endocrinology Diabetes type-2 and the metabolic syndrome are prevalent in epidemic proportions and result in significant co-morbid disease. Limitations in understanding of dietary effects and cholesterol metabolism exist. Current methods to assess diabetes are essential, though many are invasive; for example, blood glucose and lipid monitoring require regular finger sticks and blood draws. A novel method to study these diseases may be non-invasive breath testing of exhaled compounds. Currently, acetone and lipid peroxidation products have been seen in small scale studies, though other compounds may be significant. As Atlantic bottlenose dolphins (Tursiops truncatus) have been proposed as a good model for human diabetes, applications of dietary manipulations and breath testing in this population may shed important light on how to design human clinical studies. In addition, ongoing studies indicate that breath testing in dolphins is feasible, humane, and yields relevant metabolites. By studying the metabolic and cholesterol responses of dolphins to dietary modifications, researchers may gain insight into human diabetes, improve the design of costly human clinical trials, and potentially discover biomarkers for non-invasive breath monitoring. Frontiers Media S.A. 2013-11-25 /pmc/articles/PMC3839089/ /pubmed/24324455 http://dx.doi.org/10.3389/fendo.2013.00163 Text en Copyright © 2013 Schivo, Aksenov, Yeates, Pasamontes and Davis. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Schivo, Michael
Aksenov, Alexander A.
Yeates, Laura C.
Pasamontes, Alberto
Davis, Cristina E.
Diabetes and the Metabolic Syndrome: Possibilities of a New Breath Test in a Dolphin Model
title Diabetes and the Metabolic Syndrome: Possibilities of a New Breath Test in a Dolphin Model
title_full Diabetes and the Metabolic Syndrome: Possibilities of a New Breath Test in a Dolphin Model
title_fullStr Diabetes and the Metabolic Syndrome: Possibilities of a New Breath Test in a Dolphin Model
title_full_unstemmed Diabetes and the Metabolic Syndrome: Possibilities of a New Breath Test in a Dolphin Model
title_short Diabetes and the Metabolic Syndrome: Possibilities of a New Breath Test in a Dolphin Model
title_sort diabetes and the metabolic syndrome: possibilities of a new breath test in a dolphin model
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839089/
https://www.ncbi.nlm.nih.gov/pubmed/24324455
http://dx.doi.org/10.3389/fendo.2013.00163
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