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Neuropilin-1 in Transplantation Tolerance
In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells. Recently, Nrp1 has been identified as a marker that seems to distinguish natural T regulatory (nTreg) cells, generated in the thym...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839227/ https://www.ncbi.nlm.nih.gov/pubmed/24324469 http://dx.doi.org/10.3389/fimmu.2013.00405 |
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author | Campos-Mora, Mauricio Morales, Rodrigo A. Gajardo, Tania Catalán, Diego Pino-Lagos, Karina |
author_facet | Campos-Mora, Mauricio Morales, Rodrigo A. Gajardo, Tania Catalán, Diego Pino-Lagos, Karina |
author_sort | Campos-Mora, Mauricio |
collection | PubMed |
description | In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells. Recently, Nrp1 has been identified as a marker that seems to distinguish natural T regulatory (nTreg) cells, generated in the thymus, from inducible T regulatory (iTreg) cells raised in the periphery. Given the crucial role of both nTreg and iTreg cells in the generation and maintenance of immune tolerance, the ability to phenotypically identify each of these cell populations in vivo is needed to elucidate their biological properties. In turn, these properties have the potential to be developed for therapeutic use to promote immune tolerance. Here we describe the nature and functions of Nrp1, including its potential use as a therapeutic target in transplantation tolerance. |
format | Online Article Text |
id | pubmed-3839227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38392272013-12-09 Neuropilin-1 in Transplantation Tolerance Campos-Mora, Mauricio Morales, Rodrigo A. Gajardo, Tania Catalán, Diego Pino-Lagos, Karina Front Immunol Immunology In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells. Recently, Nrp1 has been identified as a marker that seems to distinguish natural T regulatory (nTreg) cells, generated in the thymus, from inducible T regulatory (iTreg) cells raised in the periphery. Given the crucial role of both nTreg and iTreg cells in the generation and maintenance of immune tolerance, the ability to phenotypically identify each of these cell populations in vivo is needed to elucidate their biological properties. In turn, these properties have the potential to be developed for therapeutic use to promote immune tolerance. Here we describe the nature and functions of Nrp1, including its potential use as a therapeutic target in transplantation tolerance. Frontiers Media S.A. 2013-11-25 /pmc/articles/PMC3839227/ /pubmed/24324469 http://dx.doi.org/10.3389/fimmu.2013.00405 Text en Copyright © 2013 Campos-Mora, Morales, Gajardo, Catalán and Pino-Lagos. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Campos-Mora, Mauricio Morales, Rodrigo A. Gajardo, Tania Catalán, Diego Pino-Lagos, Karina Neuropilin-1 in Transplantation Tolerance |
title | Neuropilin-1 in Transplantation Tolerance |
title_full | Neuropilin-1 in Transplantation Tolerance |
title_fullStr | Neuropilin-1 in Transplantation Tolerance |
title_full_unstemmed | Neuropilin-1 in Transplantation Tolerance |
title_short | Neuropilin-1 in Transplantation Tolerance |
title_sort | neuropilin-1 in transplantation tolerance |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839227/ https://www.ncbi.nlm.nih.gov/pubmed/24324469 http://dx.doi.org/10.3389/fimmu.2013.00405 |
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