HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls

The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according t...

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Detalles Bibliográficos
Autores principales: Oguz, Fatma Savran, Ocal, Lale, Diler, Ali Sarper, Ozkul, Hilmi, Asicioglu, Faruk, Kasapoglu, Esen, Bozkurt, Gokay, Konice, Meral, Carin, Mahmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2004
Materias:
Other
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839277/
https://www.ncbi.nlm.nih.gov/pubmed/15665390
http://dx.doi.org/10.1155/2004/565270
Descripción
Sumario:The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B(∗)27 was 2.6% in the Turkish population, and B(∗)2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B(∗)2705 among B27-positive patients and controls was significantly different (P = 0.02). Our study supports other reports from different populations which showed that B(∗)2705 and B(∗)2702 were more frequent in Caucasian patients with SpA.

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