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Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants

OBJECTIVES: UK Biobank is a landmark cohort of over 500,000 participants which will be used to investigate genetic and non-genetic risk factors for a wide range of adverse health outcomes. This is the first study to systematically assess the prevalence and validity of proposed criteria for probable...

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Autores principales: Smith, Daniel J., Nicholl, Barbara I., Cullen, Breda, Martin, Daniel, Ul-Haq, Zia, Evans, Jonathan, Gill, Jason M. R., Roberts, Beverly, Gallacher, John, Mackay, Daniel, Hotopf, Matthew, Deary, Ian, Craddock, Nick, Pell, Jill P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839907/
https://www.ncbi.nlm.nih.gov/pubmed/24282498
http://dx.doi.org/10.1371/journal.pone.0075362
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author Smith, Daniel J.
Nicholl, Barbara I.
Cullen, Breda
Martin, Daniel
Ul-Haq, Zia
Evans, Jonathan
Gill, Jason M. R.
Roberts, Beverly
Gallacher, John
Mackay, Daniel
Hotopf, Matthew
Deary, Ian
Craddock, Nick
Pell, Jill P.
author_facet Smith, Daniel J.
Nicholl, Barbara I.
Cullen, Breda
Martin, Daniel
Ul-Haq, Zia
Evans, Jonathan
Gill, Jason M. R.
Roberts, Beverly
Gallacher, John
Mackay, Daniel
Hotopf, Matthew
Deary, Ian
Craddock, Nick
Pell, Jill P.
author_sort Smith, Daniel J.
collection PubMed
description OBJECTIVES: UK Biobank is a landmark cohort of over 500,000 participants which will be used to investigate genetic and non-genetic risk factors for a wide range of adverse health outcomes. This is the first study to systematically assess the prevalence and validity of proposed criteria for probable mood disorders within the cohort (major depression and bipolar disorder). METHODS: This was a descriptive epidemiological study of 172,751 individuals assessed for a lifetime history of mood disorder in relation to a range of demographic, social, lifestyle, personality and health-related factors. The main outcomes were prevalence of a probable lifetime (single) episode of major depression, probable recurrent major depressive disorder (moderate), probable recurrent major depressive disorder (severe), probable bipolar disorder and no history of mood disorder (comparison group). Outcomes were compared on age, gender, ethnicity, socioeconomic status, educational attainment, functioning, self-reported health status, current depressive symptoms, neuroticism score, smoking status and alcohol use. RESULTS: Prevalence rates for probable single lifetime episode of major depression (6.4%), probable recurrent major depression (moderate) (12.2%), probable recurrent major depression (severe) (7.2%) and probable bipolar disorder (1.3%) were comparable to those found in other population studies. The proposed diagnostic criteria have promising validity, with a gradient in evidence from no mood disorder through major depression and probable bipolar disorder in terms of gender distribution, socioeconomic status, self-reported health rating, current depressive symptoms and smoking. SIGNIFICANCE: The validity of our proposed criteria for probable major depression and probable bipolar disorder within this cohort are supported by these cross-sectional analyses. Our findings are likely to prove useful as a framework for a wide range of future genetic and non-genetic studies.
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spelling pubmed-38399072013-11-26 Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants Smith, Daniel J. Nicholl, Barbara I. Cullen, Breda Martin, Daniel Ul-Haq, Zia Evans, Jonathan Gill, Jason M. R. Roberts, Beverly Gallacher, John Mackay, Daniel Hotopf, Matthew Deary, Ian Craddock, Nick Pell, Jill P. PLoS One Research Article OBJECTIVES: UK Biobank is a landmark cohort of over 500,000 participants which will be used to investigate genetic and non-genetic risk factors for a wide range of adverse health outcomes. This is the first study to systematically assess the prevalence and validity of proposed criteria for probable mood disorders within the cohort (major depression and bipolar disorder). METHODS: This was a descriptive epidemiological study of 172,751 individuals assessed for a lifetime history of mood disorder in relation to a range of demographic, social, lifestyle, personality and health-related factors. The main outcomes were prevalence of a probable lifetime (single) episode of major depression, probable recurrent major depressive disorder (moderate), probable recurrent major depressive disorder (severe), probable bipolar disorder and no history of mood disorder (comparison group). Outcomes were compared on age, gender, ethnicity, socioeconomic status, educational attainment, functioning, self-reported health status, current depressive symptoms, neuroticism score, smoking status and alcohol use. RESULTS: Prevalence rates for probable single lifetime episode of major depression (6.4%), probable recurrent major depression (moderate) (12.2%), probable recurrent major depression (severe) (7.2%) and probable bipolar disorder (1.3%) were comparable to those found in other population studies. The proposed diagnostic criteria have promising validity, with a gradient in evidence from no mood disorder through major depression and probable bipolar disorder in terms of gender distribution, socioeconomic status, self-reported health rating, current depressive symptoms and smoking. SIGNIFICANCE: The validity of our proposed criteria for probable major depression and probable bipolar disorder within this cohort are supported by these cross-sectional analyses. Our findings are likely to prove useful as a framework for a wide range of future genetic and non-genetic studies. Public Library of Science 2013-11-25 /pmc/articles/PMC3839907/ /pubmed/24282498 http://dx.doi.org/10.1371/journal.pone.0075362 Text en © 2013 Smith et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Smith, Daniel J.
Nicholl, Barbara I.
Cullen, Breda
Martin, Daniel
Ul-Haq, Zia
Evans, Jonathan
Gill, Jason M. R.
Roberts, Beverly
Gallacher, John
Mackay, Daniel
Hotopf, Matthew
Deary, Ian
Craddock, Nick
Pell, Jill P.
Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants
title Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants
title_full Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants
title_fullStr Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants
title_full_unstemmed Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants
title_short Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants
title_sort prevalence and characteristics of probable major depression and bipolar disorder within uk biobank: cross-sectional study of 172,751 participants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839907/
https://www.ncbi.nlm.nih.gov/pubmed/24282498
http://dx.doi.org/10.1371/journal.pone.0075362
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