Effects of Highly Conserved Major Histocompatibility Complex (MHC) Extended Haplotypes on Iron and Low CD8(+) T Lymphocyte Phenotypes in HFE C282Y Homozygous Hemochromatosis Patients from Three Geographically Distant Areas

Hereditary Hemochromatosis (HH) is a recessively inherited disorder of iron overload occurring commonly in subjects homozygous for the C282Y mutation in HFE gene localized on chromosome 6p21.3 in linkage disequilibrium with the human leukocyte antigen (HLA)-A locus. Although its genetic homogeneity,...

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Detalles Bibliográficos
Autores principales: Costa, Mónica, Cruz, Eugénia, Barton, James C., Thorstensen, Ketil, Morais, Sandra, da Silva, Berta M., Pinto, Jorge P., Vieira, Cristina P., Vieira, Jorge, Acton, Ronald T., Porto, Graça
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839968/
https://www.ncbi.nlm.nih.gov/pubmed/24282517
http://dx.doi.org/10.1371/journal.pone.0079990

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