Cargando…

The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease

The detection of α-synuclein (α-syn) in the cerebrospinal fluid (CSF) of patients with synucleinopathy has yielded promising but inconclusive results. The aim of the present study was to determine the diagnostic value of α-syn as a biological marker for Dementia with Lewy bodies (DLB) vs. normal sub...

Descripción completa

Detalles Bibliográficos
Autores principales: Kapaki, Elisabeth, Paraskevas, George P., Emmanouilidou, Evangelia, Vekrellis, Kostas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840054/
https://www.ncbi.nlm.nih.gov/pubmed/24282614
http://dx.doi.org/10.1371/journal.pone.0081654
_version_ 1782478473111011328
author Kapaki, Elisabeth
Paraskevas, George P.
Emmanouilidou, Evangelia
Vekrellis, Kostas
author_facet Kapaki, Elisabeth
Paraskevas, George P.
Emmanouilidou, Evangelia
Vekrellis, Kostas
author_sort Kapaki, Elisabeth
collection PubMed
description The detection of α-synuclein (α-syn) in the cerebrospinal fluid (CSF) of patients with synucleinopathy has yielded promising but inconclusive results. The aim of the present study was to determine the diagnostic value of α-syn as a biological marker for Dementia with Lewy bodies (DLB) vs. normal subjects and patients with Alzheimer’s disease (AD), after strict control of several recognized confounders. Sixteen patients with DLB, 18 patients with AD and 22 age- and sex-matched normal controls (CTRL) were recruited. The levels of total α-syn in CSF were measured using a novel enzyme-linked immunosorbent assay. There was a significant increase of CSF α-syn levels in DLB patients as compared to the CTRL and AD groups (P= 0.049 and 0.01 respectively). ROC analysis revealed that increased α-syn was 81.8% specific for the discrimination of DLB vs. CTRL and 90% vs. AD. However, sensitivity was lower (56.2 % and 50% respectively). These findings provide evidence for a possible diagnostic role of α-syn as a surrogate biomarker for DLB.
format Online
Article
Text
id pubmed-3840054
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-38400542013-11-26 The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease Kapaki, Elisabeth Paraskevas, George P. Emmanouilidou, Evangelia Vekrellis, Kostas PLoS One Research Article The detection of α-synuclein (α-syn) in the cerebrospinal fluid (CSF) of patients with synucleinopathy has yielded promising but inconclusive results. The aim of the present study was to determine the diagnostic value of α-syn as a biological marker for Dementia with Lewy bodies (DLB) vs. normal subjects and patients with Alzheimer’s disease (AD), after strict control of several recognized confounders. Sixteen patients with DLB, 18 patients with AD and 22 age- and sex-matched normal controls (CTRL) were recruited. The levels of total α-syn in CSF were measured using a novel enzyme-linked immunosorbent assay. There was a significant increase of CSF α-syn levels in DLB patients as compared to the CTRL and AD groups (P= 0.049 and 0.01 respectively). ROC analysis revealed that increased α-syn was 81.8% specific for the discrimination of DLB vs. CTRL and 90% vs. AD. However, sensitivity was lower (56.2 % and 50% respectively). These findings provide evidence for a possible diagnostic role of α-syn as a surrogate biomarker for DLB. Public Library of Science 2013-11-25 /pmc/articles/PMC3840054/ /pubmed/24282614 http://dx.doi.org/10.1371/journal.pone.0081654 Text en © 2013 Kapaki et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kapaki, Elisabeth
Paraskevas, George P.
Emmanouilidou, Evangelia
Vekrellis, Kostas
The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease
title The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease
title_full The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease
title_fullStr The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease
title_full_unstemmed The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease
title_short The Diagnostic Value of CSF α-Synuclein in the Differential Diagnosis of Dementia with Lewy Bodies vs. Normal Subjects and Patients with Alzheimer’s Disease
title_sort diagnostic value of csf α-synuclein in the differential diagnosis of dementia with lewy bodies vs. normal subjects and patients with alzheimer’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840054/
https://www.ncbi.nlm.nih.gov/pubmed/24282614
http://dx.doi.org/10.1371/journal.pone.0081654
work_keys_str_mv AT kapakielisabeth thediagnosticvalueofcsfasynucleininthedifferentialdiagnosisofdementiawithlewybodiesvsnormalsubjectsandpatientswithalzheimersdisease
AT paraskevasgeorgep thediagnosticvalueofcsfasynucleininthedifferentialdiagnosisofdementiawithlewybodiesvsnormalsubjectsandpatientswithalzheimersdisease
AT emmanouilidouevangelia thediagnosticvalueofcsfasynucleininthedifferentialdiagnosisofdementiawithlewybodiesvsnormalsubjectsandpatientswithalzheimersdisease
AT vekrelliskostas thediagnosticvalueofcsfasynucleininthedifferentialdiagnosisofdementiawithlewybodiesvsnormalsubjectsandpatientswithalzheimersdisease
AT kapakielisabeth diagnosticvalueofcsfasynucleininthedifferentialdiagnosisofdementiawithlewybodiesvsnormalsubjectsandpatientswithalzheimersdisease
AT paraskevasgeorgep diagnosticvalueofcsfasynucleininthedifferentialdiagnosisofdementiawithlewybodiesvsnormalsubjectsandpatientswithalzheimersdisease
AT emmanouilidouevangelia diagnosticvalueofcsfasynucleininthedifferentialdiagnosisofdementiawithlewybodiesvsnormalsubjectsandpatientswithalzheimersdisease
AT vekrelliskostas diagnosticvalueofcsfasynucleininthedifferentialdiagnosisofdementiawithlewybodiesvsnormalsubjectsandpatientswithalzheimersdisease