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Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake

Glucocorticoids increase adipocyte proliferation and differentiation, a process underpinned by the local reactivation of inactive cortisone to active cortisol within adipocytes catalyzed by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The adrenal sex steroid precursor dehydroepiandrosterone (...

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Detalles Bibliográficos
Autores principales: McNelis, Joanne C., Manolopoulos, Konstantinos N., Gathercole, Laura L., Bujalska, Iwona J., Stewart, Paul M., Tomlinson, Jeremy W., Arlt, Wiebke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840204/
https://www.ncbi.nlm.nih.gov/pubmed/24022868
http://dx.doi.org/10.1152/ajpendo.00314.2012