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Subversion of inflammasome activation and pyroptosis by pathogenic bacteria

Activation of the inflammasome occurs in response to a notably high number of pathogenic microbes and is a broad innate immune response that effectively contributes to restriction of pathogen replication and generation of adaptive immunity. Activation of these platforms leads to caspase-1- and/or ca...

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Detalles Bibliográficos
Autores principales: Cunha, Larissa D., Zamboni, Dario S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840304/
https://www.ncbi.nlm.nih.gov/pubmed/24324933
http://dx.doi.org/10.3389/fcimb.2013.00076
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author Cunha, Larissa D.
Zamboni, Dario S.
author_facet Cunha, Larissa D.
Zamboni, Dario S.
author_sort Cunha, Larissa D.
collection PubMed
description Activation of the inflammasome occurs in response to a notably high number of pathogenic microbes and is a broad innate immune response that effectively contributes to restriction of pathogen replication and generation of adaptive immunity. Activation of these platforms leads to caspase-1- and/or caspase-11-dependent secretion of proteins, including cytokines, and induction of a specific form of cell death called pyroptosis, which directly or indirectly contribute for restriction of pathogen replication. Not surprisingly, bona fide intracellular pathogens developed strategies for manipulation of cell death to guarantee intracellular replication. In this sense, the remarkable advances in the knowledge of the inflammasome field have been accompanied by several reports characterizing the inhibition of this platform by several pathogenic bacteria. Herein, we review some processes used by pathogenic bacteria, including Yersinia spp., Pseudomonas aeruginosa, Vibrio parahaemolyticus, Chlamydia trachomatis, Francisella tularensis, Shigella flexneri, Legionella pneumophila, and Coxiella burnetii to evade the activation of the inflammasome and the induction of pyroptosis.
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spelling pubmed-38403042013-12-09 Subversion of inflammasome activation and pyroptosis by pathogenic bacteria Cunha, Larissa D. Zamboni, Dario S. Front Cell Infect Microbiol Microbiology Activation of the inflammasome occurs in response to a notably high number of pathogenic microbes and is a broad innate immune response that effectively contributes to restriction of pathogen replication and generation of adaptive immunity. Activation of these platforms leads to caspase-1- and/or caspase-11-dependent secretion of proteins, including cytokines, and induction of a specific form of cell death called pyroptosis, which directly or indirectly contribute for restriction of pathogen replication. Not surprisingly, bona fide intracellular pathogens developed strategies for manipulation of cell death to guarantee intracellular replication. In this sense, the remarkable advances in the knowledge of the inflammasome field have been accompanied by several reports characterizing the inhibition of this platform by several pathogenic bacteria. Herein, we review some processes used by pathogenic bacteria, including Yersinia spp., Pseudomonas aeruginosa, Vibrio parahaemolyticus, Chlamydia trachomatis, Francisella tularensis, Shigella flexneri, Legionella pneumophila, and Coxiella burnetii to evade the activation of the inflammasome and the induction of pyroptosis. Frontiers Media S.A. 2013-11-26 /pmc/articles/PMC3840304/ /pubmed/24324933 http://dx.doi.org/10.3389/fcimb.2013.00076 Text en Copyright © 2013 Cunha and Zamboni. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Cunha, Larissa D.
Zamboni, Dario S.
Subversion of inflammasome activation and pyroptosis by pathogenic bacteria
title Subversion of inflammasome activation and pyroptosis by pathogenic bacteria
title_full Subversion of inflammasome activation and pyroptosis by pathogenic bacteria
title_fullStr Subversion of inflammasome activation and pyroptosis by pathogenic bacteria
title_full_unstemmed Subversion of inflammasome activation and pyroptosis by pathogenic bacteria
title_short Subversion of inflammasome activation and pyroptosis by pathogenic bacteria
title_sort subversion of inflammasome activation and pyroptosis by pathogenic bacteria
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840304/
https://www.ncbi.nlm.nih.gov/pubmed/24324933
http://dx.doi.org/10.3389/fcimb.2013.00076
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