Next-generation transgenic mice for optogenetic analysis of neural circuits

Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit p...

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Detalles Bibliográficos
Autores principales: Asrican, Brent, Augustine, George J., Berglund, Ken, Chen, Susu, Chow, Nick, Deisseroth, Karl, Feng, Guoping, Gloss, Bernd, Hira, Riichiro, Hoffmann, Carolin, Kasai, Haruo, Katarya, Malvika, Kim, Jinsook, Kudolo, John, Lee, Li Ming, Lo, Shun Qiang, Mancuso, James, Matsuzaki, Masanori, Nakajima, Ryuichi, Qiu, Li, Tan, Gregory, Tang, Yanxia, Ting, Jonathan T., Tsuda, Sachiko, Wen, Lei, Zhang, Xuying, Zhao, Shengli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840435/
https://www.ncbi.nlm.nih.gov/pubmed/24324405
http://dx.doi.org/10.3389/fncir.2013.00160
Descripción
Sumario:Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.

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