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Next-generation transgenic mice for optogenetic analysis of neural circuits
Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit p...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840435/ https://www.ncbi.nlm.nih.gov/pubmed/24324405 http://dx.doi.org/10.3389/fncir.2013.00160 |
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| author | Asrican, Brent Augustine, George J. Berglund, Ken Chen, Susu Chow, Nick Deisseroth, Karl Feng, Guoping Gloss, Bernd Hira, Riichiro Hoffmann, Carolin Kasai, Haruo Katarya, Malvika Kim, Jinsook Kudolo, John Lee, Li Ming Lo, Shun Qiang Mancuso, James Matsuzaki, Masanori Nakajima, Ryuichi Qiu, Li Tan, Gregory Tang, Yanxia Ting, Jonathan T. Tsuda, Sachiko Wen, Lei Zhang, Xuying Zhao, Shengli |
| author_facet | Asrican, Brent Augustine, George J. Berglund, Ken Chen, Susu Chow, Nick Deisseroth, Karl Feng, Guoping Gloss, Bernd Hira, Riichiro Hoffmann, Carolin Kasai, Haruo Katarya, Malvika Kim, Jinsook Kudolo, John Lee, Li Ming Lo, Shun Qiang Mancuso, James Matsuzaki, Masanori Nakajima, Ryuichi Qiu, Li Tan, Gregory Tang, Yanxia Ting, Jonathan T. Tsuda, Sachiko Wen, Lei Zhang, Xuying Zhao, Shengli |
| author_sort | Asrican, Brent |
| collection | PubMed |
| description | Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice. |
| format | Online Article Text |
| id | pubmed-3840435 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-38404352013-12-09 Next-generation transgenic mice for optogenetic analysis of neural circuits Asrican, Brent Augustine, George J. Berglund, Ken Chen, Susu Chow, Nick Deisseroth, Karl Feng, Guoping Gloss, Bernd Hira, Riichiro Hoffmann, Carolin Kasai, Haruo Katarya, Malvika Kim, Jinsook Kudolo, John Lee, Li Ming Lo, Shun Qiang Mancuso, James Matsuzaki, Masanori Nakajima, Ryuichi Qiu, Li Tan, Gregory Tang, Yanxia Ting, Jonathan T. Tsuda, Sachiko Wen, Lei Zhang, Xuying Zhao, Shengli Front Neural Circuits Neuroscience Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice. Frontiers Media S.A. 2013-11-26 /pmc/articles/PMC3840435/ /pubmed/24324405 http://dx.doi.org/10.3389/fncir.2013.00160 Text en Copyright © 2013 Asrican, Augustine, Berglund, Chen, Chow, Deisseroth, Feng, Gloss, Hira, Hoffmann, Kasai, Katarya, Kim, Kudolo, Lee, Lo, Mancuso, Matsuzaki, Nakajima, Qiu, Tan, Tang, Ting, Tsuda, Wen, Zhang and Zhao. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Neuroscience Asrican, Brent Augustine, George J. Berglund, Ken Chen, Susu Chow, Nick Deisseroth, Karl Feng, Guoping Gloss, Bernd Hira, Riichiro Hoffmann, Carolin Kasai, Haruo Katarya, Malvika Kim, Jinsook Kudolo, John Lee, Li Ming Lo, Shun Qiang Mancuso, James Matsuzaki, Masanori Nakajima, Ryuichi Qiu, Li Tan, Gregory Tang, Yanxia Ting, Jonathan T. Tsuda, Sachiko Wen, Lei Zhang, Xuying Zhao, Shengli Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_full | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_fullStr | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_full_unstemmed | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_short | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_sort | next-generation transgenic mice for optogenetic analysis of neural circuits |
| topic | Neuroscience |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840435/ https://www.ncbi.nlm.nih.gov/pubmed/24324405 http://dx.doi.org/10.3389/fncir.2013.00160 |
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