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Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness
Pancreatic ductal adenocarcinoma remains one of the most lethal of all solid tumors with an overall five-year survival rate of only 3–5%. Its aggressive biology and resistance to conventional and targeted therapeutic agents lead to a typical clinical presentation of incurable disease once diagnosed....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840441/ https://www.ncbi.nlm.nih.gov/pubmed/24281221 http://dx.doi.org/10.3390/cancers2042138 |
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author | Vasseur, Sophie Tomasini, Richard Tournaire, Roselyne Iovanna, Juan L. |
author_facet | Vasseur, Sophie Tomasini, Richard Tournaire, Roselyne Iovanna, Juan L. |
author_sort | Vasseur, Sophie |
collection | PubMed |
description | Pancreatic ductal adenocarcinoma remains one of the most lethal of all solid tumors with an overall five-year survival rate of only 3–5%. Its aggressive biology and resistance to conventional and targeted therapeutic agents lead to a typical clinical presentation of incurable disease once diagnosed. The disease is characterized by the presence of a dense stroma of fibroblasts and inflammatory cells, termed desmoplasia, which limits the oxygen diffusion in the organ, creating a strong hypoxic environment within the tumor. In this review, we argue that hypoxia is responsible for the highly aggressive and metastatic characteristics of this tumor and drives pancreatic cancer cells to oncogenic and metabolic changes facilitating their proliferation. However, the molecular changes leading to metabolic adaptations of pancreatic cancer cells remain unclear. Cachexia is a hallmark of this disease and illustrates that this cancer is a real metabolic disease. Hence, this tumor must harbor metabolic pathways which are probably tied in a complex inter-organ dialog during the development of this cancer. Such a hypothesis would better explain how under fuel source limitation, pancreatic cancer cells are maintained, show a growth advantage, and develop metastasis. |
format | Online Article Text |
id | pubmed-3840441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38404412013-11-26 Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness Vasseur, Sophie Tomasini, Richard Tournaire, Roselyne Iovanna, Juan L. Cancers (Basel) Review Pancreatic ductal adenocarcinoma remains one of the most lethal of all solid tumors with an overall five-year survival rate of only 3–5%. Its aggressive biology and resistance to conventional and targeted therapeutic agents lead to a typical clinical presentation of incurable disease once diagnosed. The disease is characterized by the presence of a dense stroma of fibroblasts and inflammatory cells, termed desmoplasia, which limits the oxygen diffusion in the organ, creating a strong hypoxic environment within the tumor. In this review, we argue that hypoxia is responsible for the highly aggressive and metastatic characteristics of this tumor and drives pancreatic cancer cells to oncogenic and metabolic changes facilitating their proliferation. However, the molecular changes leading to metabolic adaptations of pancreatic cancer cells remain unclear. Cachexia is a hallmark of this disease and illustrates that this cancer is a real metabolic disease. Hence, this tumor must harbor metabolic pathways which are probably tied in a complex inter-organ dialog during the development of this cancer. Such a hypothesis would better explain how under fuel source limitation, pancreatic cancer cells are maintained, show a growth advantage, and develop metastasis. MDPI 2010-12-16 /pmc/articles/PMC3840441/ /pubmed/24281221 http://dx.doi.org/10.3390/cancers2042138 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Vasseur, Sophie Tomasini, Richard Tournaire, Roselyne Iovanna, Juan L. Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness |
title | Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness |
title_full | Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness |
title_fullStr | Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness |
title_full_unstemmed | Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness |
title_short | Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness |
title_sort | hypoxia induced tumor metabolic switch contributes to pancreatic cancer aggressiveness |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840441/ https://www.ncbi.nlm.nih.gov/pubmed/24281221 http://dx.doi.org/10.3390/cancers2042138 |
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