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Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression

Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasi...

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Autores principales: Krantz, Seth B., Shields, Mario A., Dangi-Garimella, Surabhi, Bentrem, David J., Munshi, Hidayatullah G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840442/
https://www.ncbi.nlm.nih.gov/pubmed/24281219
http://dx.doi.org/10.3390/cancers2042084
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author Krantz, Seth B.
Shields, Mario A.
Dangi-Garimella, Surabhi
Bentrem, David J.
Munshi, Hidayatullah G.
author_facet Krantz, Seth B.
Shields, Mario A.
Dangi-Garimella, Surabhi
Bentrem, David J.
Munshi, Hidayatullah G.
author_sort Krantz, Seth B.
collection PubMed
description Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.
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spelling pubmed-38404422013-11-26 Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression Krantz, Seth B. Shields, Mario A. Dangi-Garimella, Surabhi Bentrem, David J. Munshi, Hidayatullah G. Cancers (Basel) Review Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer. MDPI 2010-12-09 /pmc/articles/PMC3840442/ /pubmed/24281219 http://dx.doi.org/10.3390/cancers2042084 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Krantz, Seth B.
Shields, Mario A.
Dangi-Garimella, Surabhi
Bentrem, David J.
Munshi, Hidayatullah G.
Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression
title Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression
title_full Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression
title_fullStr Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression
title_full_unstemmed Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression
title_short Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression
title_sort contribution of epithelial-mesenchymal transition to pancreatic cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840442/
https://www.ncbi.nlm.nih.gov/pubmed/24281219
http://dx.doi.org/10.3390/cancers2042084
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