Epithelial-Mesenchymal Transition in Pancreatic Carcinoma

Pancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial char...

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Detalles Bibliográficos
Autores principales: Maier, Harald J., Wirth, Thomas, Beug, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840444/
https://www.ncbi.nlm.nih.gov/pubmed/24281218
http://dx.doi.org/10.3390/cancers2042058
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author Maier, Harald J.
Wirth, Thomas
Beug, Hartmut
author_facet Maier, Harald J.
Wirth, Thomas
Beug, Hartmut
author_sort Maier, Harald J.
collection PubMed
description Pancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial characteristics and gain properties of mesenchymal cells, such as enhanced motility and invasive features. This review will discuss recent findings pertinent to EMT in pancreatic carcinoma. Evidence for and molecular characteristics of EMT in pancreatic carcinoma will be outlined, as well as the connection of EMT to related topics, e.g., cancer stem cells and drug resistance.
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spelling pubmed-38404442013-11-26 Epithelial-Mesenchymal Transition in Pancreatic Carcinoma Maier, Harald J. Wirth, Thomas Beug, Hartmut Cancers (Basel) Review Pancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial characteristics and gain properties of mesenchymal cells, such as enhanced motility and invasive features. This review will discuss recent findings pertinent to EMT in pancreatic carcinoma. Evidence for and molecular characteristics of EMT in pancreatic carcinoma will be outlined, as well as the connection of EMT to related topics, e.g., cancer stem cells and drug resistance. MDPI 2010-12-09 /pmc/articles/PMC3840444/ /pubmed/24281218 http://dx.doi.org/10.3390/cancers2042058 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Maier, Harald J.
Wirth, Thomas
Beug, Hartmut
Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
title Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
title_full Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
title_fullStr Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
title_full_unstemmed Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
title_short Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
title_sort epithelial-mesenchymal transition in pancreatic carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840444/
https://www.ncbi.nlm.nih.gov/pubmed/24281218
http://dx.doi.org/10.3390/cancers2042058
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