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Familial Pancreatic Cancer
Pancreatic cancer’s high mortality rate equates closely with its incidence, thereby showing the need for development of biomarkers of its increased risk and a better understanding of its genetics, so that high-risk patients can be better targeted for screening and early potential lifesaving diagnosi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840451/ https://www.ncbi.nlm.nih.gov/pubmed/24281205 http://dx.doi.org/10.3390/cancers2041861 |
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author | Lynch, Henry T. Lynch, Jane F. Lanspa, Stephen J. |
author_facet | Lynch, Henry T. Lynch, Jane F. Lanspa, Stephen J. |
author_sort | Lynch, Henry T. |
collection | PubMed |
description | Pancreatic cancer’s high mortality rate equates closely with its incidence, thereby showing the need for development of biomarkers of its increased risk and a better understanding of its genetics, so that high-risk patients can be better targeted for screening and early potential lifesaving diagnosis. Its phenotypic and genotypic heterogeneity is extensive and requires careful scrutiny of its pattern of cancer associations, such as malignant melanoma associated with pancreatic cancer, in the familial atypical multiple mole melanoma syndrome, due to the CDKN2A germline mutation. This review is designed to depict several of the hereditary pancreatic cancer syndromes with particular attention given to the clinical application of this knowledge into improved control of pancreatic cancer. |
format | Online Article Text |
id | pubmed-3840451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38404512013-11-26 Familial Pancreatic Cancer Lynch, Henry T. Lynch, Jane F. Lanspa, Stephen J. Cancers (Basel) Review Pancreatic cancer’s high mortality rate equates closely with its incidence, thereby showing the need for development of biomarkers of its increased risk and a better understanding of its genetics, so that high-risk patients can be better targeted for screening and early potential lifesaving diagnosis. Its phenotypic and genotypic heterogeneity is extensive and requires careful scrutiny of its pattern of cancer associations, such as malignant melanoma associated with pancreatic cancer, in the familial atypical multiple mole melanoma syndrome, due to the CDKN2A germline mutation. This review is designed to depict several of the hereditary pancreatic cancer syndromes with particular attention given to the clinical application of this knowledge into improved control of pancreatic cancer. MDPI 2010-11-10 /pmc/articles/PMC3840451/ /pubmed/24281205 http://dx.doi.org/10.3390/cancers2041861 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Lynch, Henry T. Lynch, Jane F. Lanspa, Stephen J. Familial Pancreatic Cancer |
title | Familial Pancreatic Cancer |
title_full | Familial Pancreatic Cancer |
title_fullStr | Familial Pancreatic Cancer |
title_full_unstemmed | Familial Pancreatic Cancer |
title_short | Familial Pancreatic Cancer |
title_sort | familial pancreatic cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840451/ https://www.ncbi.nlm.nih.gov/pubmed/24281205 http://dx.doi.org/10.3390/cancers2041861 |
work_keys_str_mv | AT lynchhenryt familialpancreaticcancer AT lynchjanef familialpancreaticcancer AT lanspastephenj familialpancreaticcancer |