Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes

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Varieties of transforming growth factor-β (TGF-β) antagonists have been developed to intervene with excessive TGF-β signalling activity in cancer. Activin receptor-like kinase5 (ALK5) inhibitors antagonize TGF-β signalling by blocking TGF-β receptor-activated Smad (R-Smad) phosphorylation. Here we r...

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Detalles Bibliográficos
Autores principales: Yoon, Jeong-Hwan, Jung, Su Myung, Park, Seok Hee, Kato, Mitsuyasu, Yamashita, Tadashi, Lee, In-Kyu, Sudo, Katsuko, Nakae, Susumu, Han, Jin Soo, Kim, Ok-Hee, Oh, Byung-Chul, Sumida, Takayuki, Kuroda, Masahiko, Ju, Ji-Hyeon, Jung, Kyeong Cheon, Park, Seong Hoe, Kim, Dae-Kee, Mamura, Mizuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840488/
https://www.ncbi.nlm.nih.gov/pubmed/24127404
http://dx.doi.org/10.1002/emmm.201302524
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