CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

Atrophic age-related macular degeneration (AMD) is associated with the subretinal accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal degeneration is unknown. We here show that atrophic AMD is associated with increased intraocular CCL2 levels and subretinal CC...

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Detalles Bibliográficos
Autores principales: Sennlaub, Florian, Auvynet, Constance, Calippe, Bertrand, Lavalette, Sophie, Poupel, Lucie, Hu, Shulong J, Dominguez, Elisa, Camelo, Serge, Levy, Olivier, Guyon, Elodie, Saederup, Noah, Charo, Israel F, Van Rooijen, Nico, Nandrot, Emeline, Bourges, Jean-Louis, Behar-Cohen, Francine, Sahel, José-Alain, Guillonneau, Xavier, Raoul, William, Combadiere, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840491/
https://www.ncbi.nlm.nih.gov/pubmed/24142887
http://dx.doi.org/10.1002/emmm.201302692

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