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Feasibility of Tomotherapy-Based Image-Guided Radiotherapy for Small Cell Lung Cancer

Background: To assess the tolerance of patients with small cell lung cancer undergoing chemoradiation with tomotherapy-based image-guided radiotherapy (IGRT). Materials and Methods: A retrospective review of the toxicity profile for nine patients with small cell lung cancer of the limited stage who...

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Detalles Bibliográficos
Autores principales: Nguyen, Nam P., Shen, Wei, Kratz, Sarah, Vock, Jacqueline, Vos, Paul, Vincent, Vinh-Hung, Altdorfer, Gabor, Ewell, Lars, Jang, Siyoung, Karlsson, Ulf, Godinez, Juan, Mills, Melissa, Sroka, Thomas, Dutta, Suresh, Chi, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840493/
https://www.ncbi.nlm.nih.gov/pubmed/24324932
http://dx.doi.org/10.3389/fonc.2013.00289
Descripción
Sumario:Background: To assess the tolerance of patients with small cell lung cancer undergoing chemoradiation with tomotherapy-based image-guided radiotherapy (IGRT). Materials and Methods: A retrospective review of the toxicity profile for nine patients with small cell lung cancer of the limited stage who underwent chemoradiation delivered with helical tomotherapy (HT) has been conducted. Results: Acute grade 3–4 hematologic and esophagitis toxicities developed in two and three patients respectively. One patient developed a pulmonary embolism during radiotherapy. Seven patients had weight loss ranging from 0 to 30 pounds (median: 4 pounds). Three patients had treatment breaks ranging from 2 to 12 days. At a median follow-up of 11 months (range: 2–24 months), no patients developed any radiation related toxicities such as grade 3–4 pneumonitis or other long-term complications. The median survival was estimated to be 15 months. There were two local recurrences, three mediastinal recurrences, and six distant metastases. Conclusion: Grade 3–4 toxicities remained significant during chemoradiation when radiation was delivered with tomotherapy-based IGRT. However, the absence of grade 3–4 pneumonitis is promising and the use of HT needs to be investigated in future prospective studies.