Cargando…
The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin
BACKGROUND: There is growing evidence indicating the insulin-like growth factor 1 receptor (IGF-1R) plays a critical role in the progression of human colorectal carcinomas. IGF-1R is an attractive drug target for the treatment of colon cancer. Picropodophyllin (PPP), of the cyclolignan family, has r...
Autores principales: | Wang, Quan, Wei, Feng, Lv, Guoyue, Li, Chunsheng, Liu, Tongjun, Hadjipanayis, Costas G, Zhang, Guikai, Hao, Chunhai, Bellail, Anita C |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840673/ https://www.ncbi.nlm.nih.gov/pubmed/24182354 http://dx.doi.org/10.1186/1471-2407-13-521 |
Ejemplares similares
-
Combination of mTOR and EGFR Kinase Inhibitors Blocks mTORC1 and mTORC2 Kinase Activity and Suppresses the Progression of Colorectal Carcinoma
por: Wang, Quan, et al.
Publicado: (2013) -
PD-0332991 induces G1 arrest of colorectal carcinoma cells through inhibition of the cyclin-dependent kinase-6 and retinoblastoma protein axis
por: LI, CHUNSHENG, et al.
Publicado: (2014) -
KRAS and TP53 Mutations in Colorectal Carcinoma
por: Al-Kuraya, Khawla S.
Publicado: (2009) -
Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via Insulin-like growth factor-1 receptor-independent mechanism
por: Waraky, Ahmed, et al.
Publicado: (2014) -
Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)
por: Hashemi, Jamileh, et al.
Publicado: (2011)