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Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies

Fouling of chromatographic resins over their operational lifetimes can be a significant problem for commercial bioseparations. In this article, scanning electron microscopy (SEM), batch uptake experiments, confocal laser scanning microscopy (CLSM) and small-scale column studies were applied to chara...

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Detalles Bibliográficos
Autores principales:	Close, Edward J, Salm, Jeffrey R, Iskra, Timothy, Sørensen, Eva, Bracewell, Daniel G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840701/ https://www.ncbi.nlm.nih.gov/pubmed/23483524 http://dx.doi.org/10.1002/bit.24898

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