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A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer
Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841101/ https://www.ncbi.nlm.nih.gov/pubmed/24302889 http://dx.doi.org/10.1371/journal.pbio.1001724 |
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author | Cruz-Ramírez, Alfredo Díaz-Triviño, Sara Wachsman, Guy Du, Yujuan Arteága-Vázquez, Mario Zhang, Hongtao Benjamins, Rene Blilou, Ikram Neef, Anne B. Chandler, Vicki Scheres, Ben |
author_facet | Cruz-Ramírez, Alfredo Díaz-Triviño, Sara Wachsman, Guy Du, Yujuan Arteága-Vázquez, Mario Zhang, Hongtao Benjamins, Rene Blilou, Ikram Neef, Anne B. Chandler, Vicki Scheres, Ben |
author_sort | Cruz-Ramírez, Alfredo |
collection | PubMed |
description | Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. Analysis of the in vivo role of quiescence in the root stem cell niche reveals that slow cycling within the QC is not needed for structural integrity of the niche but allows the growing root to cope with DNA damage. |
format | Online Article Text |
id | pubmed-3841101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38411012013-12-03 A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer Cruz-Ramírez, Alfredo Díaz-Triviño, Sara Wachsman, Guy Du, Yujuan Arteága-Vázquez, Mario Zhang, Hongtao Benjamins, Rene Blilou, Ikram Neef, Anne B. Chandler, Vicki Scheres, Ben PLoS Biol Research Article Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. Analysis of the in vivo role of quiescence in the root stem cell niche reveals that slow cycling within the QC is not needed for structural integrity of the niche but allows the growing root to cope with DNA damage. Public Library of Science 2013-11-26 /pmc/articles/PMC3841101/ /pubmed/24302889 http://dx.doi.org/10.1371/journal.pbio.1001724 Text en © 2013 Cruz-Ramírez et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Cruz-Ramírez, Alfredo Díaz-Triviño, Sara Wachsman, Guy Du, Yujuan Arteága-Vázquez, Mario Zhang, Hongtao Benjamins, Rene Blilou, Ikram Neef, Anne B. Chandler, Vicki Scheres, Ben A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer |
title | A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer |
title_full | A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer |
title_fullStr | A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer |
title_full_unstemmed | A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer |
title_short | A SCARECROW-RETINOBLASTOMA Protein Network Controls Protective Quiescence in the Arabidopsis Root Stem Cell Organizer |
title_sort | scarecrow-retinoblastoma protein network controls protective quiescence in the arabidopsis root stem cell organizer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841101/ https://www.ncbi.nlm.nih.gov/pubmed/24302889 http://dx.doi.org/10.1371/journal.pbio.1001724 |
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