Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers. Hedgehog signaling has an unusual reception system consisting of two transmembrane proteins, Patched receptor and Smoothened signal transduce...

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Detalles Bibliográficos
Autores principales: Huang, Shoujun, Zhang, Zhao, Zhang, Chunxia, Lv, Xiangdong, Zheng, Xiudeng, Chen, Zhenping, Sun, Liwei, Wang, Hailong, Zhu, Yuanxiang, Zhang, Jing, Yang, Shuyan, Lu, Yi, Sun, Qinmiao, Tao, Yi, Liu, Feng, Zhao, Yun, Chen, Dahua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841102/
https://www.ncbi.nlm.nih.gov/pubmed/24302888
http://dx.doi.org/10.1371/journal.pbio.1001721

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