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Topoisomerase I Inhibitors, Shikonin and Topotecan, Inhibit Growth and Induce Apoptosis of Glioma Cells and Glioma Stem Cells

Gliomas, the most malignant form of brain tumors, contain a small subpopulation of glioma stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence. Topoisomerase I inhibitors, shikonin and topotecan, play a crucial role in anti-cancer therapies. After isolated and identif...

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Detalles Bibliográficos
Autores principales:	Zhang, Feng-Lei, Wang, Ping, Liu, Yun-Hui, Liu, Li-bo, Liu, Xiao-Bai, Li, Zhen, Xue, Yi-Xue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841142/ https://www.ncbi.nlm.nih.gov/pubmed/24303074 http://dx.doi.org/10.1371/journal.pone.0081815

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