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Mammalian Target of Rapamycin Complex I (mTORC1) Activity in Ras Homologue Enriched in Brain (Rheb)-Deficient Mouse Embryonic Fibroblasts
The Ras-like GTPase Rheb has been identified as a crucial activator of mTORC1. Activation most likely requires a direct interaction between Rheb and mTOR, but the exact mechanism remains unclear. Using a panel of Rheb-deficient mouse embryonic fibroblasts (MEFs), we show that Rheb is indeed essentia...
Autores principales: | Groenewoud, Marlous J., Goorden, Susan M. I., Kassies, Jorien, Pellis-van Berkel, Wendy, Lamb, Richard F., Elgersma, Ype, Zwartkruis, Fried J. T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841147/ https://www.ncbi.nlm.nih.gov/pubmed/24303063 http://dx.doi.org/10.1371/journal.pone.0081649 |
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