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Direct Evidence that Scorpion α-Toxins (Site-3) Modulate Sodium Channel Inactivation by Hindrance of Voltage-Sensor Movements

The position of the voltage-sensing transmembrane segment, S4, in voltage-gated ion channels as a function of voltage remains incompletely elucidated. Site-3 toxins bind primarily to the extracellular loops connecting transmembrane helical segments S1-S2 and S3-S4 in Domain 4 (D4) and S5-S6 in Domai...

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Detalles Bibliográficos
Autores principales:	Ma, Zhongming, Kong, Jun, Gordon, Dalia, Gurevitz, Michael, Kallen, Roland G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841157/ https://www.ncbi.nlm.nih.gov/pubmed/24302985 http://dx.doi.org/10.1371/journal.pone.0077758

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